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Top AI Repos tracks AI repositories on GitHub and answers two different questions about each one: is it moving right now, and would you bet a product on it.
Top AI Repos tracks AI repositories on GitHub and answers two different questions about each one: is it moving right now, and would you bet a product on it.
Local-first, open-source Claude Science alternative, before Claude Science is a thing. Turn your AI agent into personal DNA expert.
| Date | Stars |
|---|---|
| 2026-08-05 | 474 |
| 2026-08-14 | 475 |
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| 2026-10-31 | 489 |
| 2026-11-04 | 490 |
Today
+1 stars today
This week
— stars this week
This month
+6 stars this month
Momentum
0.0
growth rate 0.00%/day
<p align="center">
<img src="assets/genomi-logo.png" alt="Genomi logo" width="160">
<br>
<strong>Your genome. Decoded.</strong>
<br>
<a href="https://www.genomiagent.com/">Website</a>
·
<a href="https://raw.githubusercontent.com/exon-research/genomi/master/INSTALL_FOR_AGENTS.md">Install guide</a>
·
<a href="README.zh-CN.md">简体中文</a>
</p>
<p align="center">
<a href="https://www.python.org/downloads/"><img alt="Python" src="https://img.shields.io/badge/python-3.10%2B-3776AB?style=flat-square&logo=python&logoColor=white&labelColor=111827"></a>
<a href="https://github.com/exon-research/genomi/releases/tag/v0.1.0"><img alt="Version" src="https://img.shields.io/badge/version-0.1.0-2563EB?style=flat-square&labelColor=111827"></a>
<a href="https://modelcontextprotocol.io/"><img alt="MCP" src="https://img.shields.io/badge/MCP-agent--native-7C3AED?style=flat-square&labelColor=111827"></a>
<a href="SKILL.md"><img alt="Skill" src="https://img.shields.io/badge/skill-agent--ready-0E7490?style=flat-square&labelColor=111827"></a>
<a href="#privacy"><img alt="Local-first" src="https://img.shields.io/badge/privacy-local--first-15803D?style=flat-square&labelColor=111827"></a>
<a href="LICENSE"><img alt="License" src="https://img.shields.io/badge/license-Apache--2.0-64748B?style=flat-square&labelColor=111827"></a>
</p>
# Genomi
> Am I going bald? What does my DNA say about Alzheimer's risk? Why does
> ibuprofen do nothing for me?
DNA is the layer underneath all of that. It shapes the proteins, enzymes,
receptors, and pathways behind nutrition, medication response, sleep,
exercise, inherited traits, and risk for some conditions. Not destiny. But
the most personal data you carry.
And it is overwhelming. ~3 billion base pairs, 20,000+ genes, millions of
observed variants per person. No clinician, no lab, no individual holds that
in their head. It is too much.
We live in an era where AI can take on tasks that were not possible before,
at scales never seen before. Your genome is exactly that kind of task. And
for the first time, we have the tools to actually read it at the scale it
lives at.
Genomi is an open-source AI agent runtime that turns your AI agent into a personal DNA expert.
Works with Claude Code, Codex, OpenClaw, Hermes, and any MCP-capable host. It gives the agent a private
workspace: your variants in a local Active Genome Index, public genetics evidence ready to
query, memory of what you explored, and report tools that turn DNA questions
into evidence-backed answers. Your genome stays on your machine. The agent
does the work.
## Launch video
<p align="center">
<a href="https://youtu.be/8CkoDNlyvZ0">
<img src="https://img.youtube.com/vi/8CkoDNlyvZ0/maxresdefault.jpg" alt="Genomi launch video" width="640">
</a>
</p>
## See it in action
- [Genomi parses your raw DNA file into a local database your agent can query](https://youtu.be/mJUw6Lf8zEk)
- [Genomi keeps your raw DNA file on your machine](https://youtu.be/Paj2ixdeZGk)
- [Genomi knows when to say "No" and "I don't know"](https://youtu.be/-yXZhFDiYP0)
- [Genomi evolves — your agent self-updates to sync with the latest research](https://youtu.be/ih_7elp2H2w)
## TL;DR
Even TL;DR is too long, just paste this to your agent:
```text
Hey please read this and tell me why Genomi is different from other AI
agent harnesses. Why is this actually useful for understanding my DNA privately?
https://raw.githubusercontent.com/exon-research/genomi/master/llms-full.txt
```
## Just Install It
Install it through your agent. Paste one instruction, answer a few questions,
and let your agent wire up the runtime:
```text
Install and configure Genomi by following the instructions here:
https://raw.githubusercontent.com/exon-research/genomi/master/INSTALL_FOR_AGENTS.md
```
The install guide covers dependency checks, library selection, MCP
registration, optional genome-source import, and verification. If Genomi is
already packaged or otherwise present, the caExcerpt of 31,131 characters
Read on GitHubWould you bet a product on this? Bounded 0–100 and slow moving.
matched fp:a4f29ee7c23ed3d6, llm:topics: agent-harness, genome-analysis, whole-genome-sequencing; description: 'Turn your AI agent into personal DNA expert' — local-first, open-source Claude Science alternative
matched fp:a4f29ee7c23ed3d6, llm:topics: agent-harness, genome-analysis, whole-genome-sequencing; description: 'Turn your AI agent into personal DNA expert' — local-first, open-source Claude Science alternative
matched fp:a4f29ee7c23ed3d6, llm:topics: agent-harness, genome-analysis, whole-genome-sequencing; description: 'Turn your AI agent into personal DNA expert' — local-first, open-source Claude Science alternative