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The COnstraint-Based Reconstruction and Analysis Toolbox. Documentation:
| Date | Stars |
|---|---|
| 2026-07-24 | 285 |
| 2026-07-25 | 285 |
| 2026-07-28 | 285 |
| 2026-07-30 | 285 |
| 2026-08-06 | 285 |
Today
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Momentum
35.0
growth rate 0.00%/day
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The COBRA Toolbox<br>
COnstraint-Based Reconstruction and Analysis Toolbox
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:target: https://github.com/opencobra/cobratoolbox/releases
:alt: Latest release version
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:target: https://github.com/opencobra/cobratoolbox/actions/workflows/build-and-publish-docs.yml
:alt: CI for building website
.. image:: https://img.shields.io/github/actions/workflow/status/opencobra/cobratoolbox/testAllCI_step2.yml?branch=master&label=CI%20For%20Testing
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The COBRA Toolbox is a comprehensive suite of functions for constraint-based modeling of biological networks. It supports the analysis of genome-scale metabolic reconstructions and other constraint-based models in MATLAB.
Resources
---------
- 📘 **Installation**: https://opencobra.github.io/cobratoolbox/stable/installation.html
- 🎓 **Tutorials**: https://opencobra.github.io/cobratoolbox/stable/tutorials/index.html
- 💬 **Community Support**: https://groups.google.com/forum/#!forum/cobra-toolbox
System Requirements and Solver Installation
-------------------------------------------
.. begin-requirements-marker
⚠️ Please follow `this guide <https://opencobra.github.io/cobratoolbox/docs/requirements.html>`__ in order to configure your system properly.
⚠️ Please make sure you install a compatible solver. Check the compatibility `here <https://opencobra.github.io/cobratoolbox/docs/compatibility.html>`__.
You may install ``TOMLAB``, ``IBM ILOG CPLEX``, ``GUROBI``, or ``MOSEK`` by following these `detailed instructions <https://opencobra.github.io/cobratoolbox/docs/solvers.html>`__.
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Installation
------------
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1. Download this repository (the folder ``./cobratoolbox/`` will be
created). You can clone the repository using:
.. code-block:: console
$ git clone --depth=1 https://github.com/opencobra/cobratoolbox.git cobratoolbox
> ⚠️ **Please note** the `--depth=1` in the clone command.
> Run this command in **Terminal** (on macOS and Linux) or in **Git Bash** (on Windows) — **not** in MATLAB.
Although not recommended, you can download the repository as a `compressed archive <https://github.com/opencobra/cobratoolbox/archive/refs/heads/master.zip>`__.
2. Change to the folder ``cobratoolbox/`` and run from MATLAB
.. code-block:: matlab
>> initCobraToolbox
.. end-installation-marker
Tutorials, Documentation, and Support
-------------------------------------
- Consult all tutorials in the section |tutorials|. All tutorials can be run from
the
`/tutorials <https://github.com/opencobra/cobratoolbox/tree/master/tutorials>`__
directory.
- All functions are documented in the |latest|.
- If you need support, please feel free to post your question in our |forum|.
- Answers to Frequently Asked Questions (**FAQ**) are
`here <https://opencobra.github.io/cobratoolbox/stable/faq.html>`__.
How to contribute
-----------------
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In order to lower the technological barrier to the use of the popular software development tool git, we have developed MATLAB.devTools, a new user-friendly software extension that enables the submission of new COBRA toolbox functions and tutorials.
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<img src="https://cdn.jsdelivr.net/gh/opencobra/MATLAB.devTools@e735bd91310e8ef10fab4d3c21833a85bf4b8159/docs/source/_static/img/logo_devToolExcerpt of 11,721 characters
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