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Top AI Repos tracks AI repositories on GitHub and answers two different questions about each one: is it moving right now, and would you bet a product on it.
Top AI Repos tracks AI repositories on GitHub and answers two different questions about each one: is it moving right now, and would you bet a product on it.
Open-source, local-first desktop AI research workbench for scientific computing with Python/R, MCP bioinformatics tools, SSH/WSL/GPU runtimes, and OpenAI/Anthropic models.
| Date | Stars |
|---|---|
| 2026-07-24 | 386 |
| 2026-07-25 | 420 |
| 2026-07-28 | 420 |
| 2026-07-30 | 420 |
| 2026-08-06 | 420 |
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Momentum
35.0
growth rate 0.00%/day
# Wisp Science — Local-first AI research workbench [English](README.md) | [简体中文](README_zh.md) <p> <a href="https://github.com/xuzhougeng/wisp-science/releases"><img src="https://img.shields.io/github/downloads/xuzhougeng/wisp-science/total" alt="Downloads"></a> <a href="https://doi.org/10.5281/zenodo.21193742"><img src="https://zenodo.org/badge/1285857639.svg" alt="DOI"></a> <a href="https://github.com/xuzhougeng/wisp-science/releases"><img src="https://img.shields.io/badge/Windows-supported-0078D4" alt="Windows supported"></a> <a href="https://github.com/xuzhougeng/wisp-science/releases"><img src="https://img.shields.io/badge/macOS-supported-000000" alt="macOS supported"></a> <a href="#build--run"><img src="https://img.shields.io/badge/Linux-source%20build-FCC624" alt="Linux source build"></a> <a href="https://github.com/xuzhougeng/wisp-science/blob/main/LICENSE"><img src="https://img.shields.io/github/license/xuzhougeng/wisp-science" alt="License"></a> <br> <a href="https://github.com/xuzhougeng/wisp-science/stargazers"><img src="https://img.shields.io/github/stars/xuzhougeng/wisp-science?style=social" alt="Stars"></a> </p> **Wisp Science** is an open-source, local-first desktop AI research assistant and scientific computing workbench. It connects to OpenAI-compatible and Anthropic models, runs persistent Python and R environments on local, SSH, WSL, and GPU compute, loads reusable Agent Skills (`SKILL.md`), and reaches ~80 bioinformatics and computational biology databases through bundled Model Context Protocol (MCP) servers. Built with Rust, Tauri v2, and Leptos, Wisp Science runs as a cross-platform desktop app or a headless CLI. > **Our manifesto:** Wisp Science is open source and borderless. We are building > a scientific workbench that anyone, anywhere can use, study, improve, and > share. > Status: MVP vertical slice. The agent loop, streaming providers, tools, > Python/R REPLs, SQLite store, MCP client, and Leptos UI all build and run. > See [Roadmap](#roadmap) for what is deferred. ## Layout ``` wisp-science/ ├─ crates/ │ ├─ wisp-llm/ Provider trait + OpenAI-compatible + Anthropic + SSE + RoutedProvider │ ├─ wisp-core/ ContextManager (3-tier compaction), SystemPrompt, agent_loop, memory │ ├─ wisp-tools/ read/write/edit/search/grep/shell/attempt_completion + Windows safety │ ├─ wisp-store/ sqlx SQLite (projects/frames/messages/artifacts/settings) + OS keyring │ ├─ wisp-skills/ SKILL.md discovery + search_skills/use_skill progressive loading │ ├─ wisp-runtime/ project-scoped Python/R runtime manager + REPL tools │ ├─ wisp-mcp/ stdio JSON-RPC MCP client + McpTool adapter (bundled bio-tools) │ ├─ wisp-acp/ ACP v1 stdio client for external coding agents │ ├─ wisp-sync/ Encrypted snapshot protocol + self-hosted relay server │ └─ wisp-cli/ `wisp-science` headless binary ├─ src-tauri/ Tauri v2 desktop shell (commands + agent event stream) ├─ ui/ Leptos CSR frontend (built by Trunk, loaded in WebView2) ├─ python/ kernel_worker.py + mock MCP server (uv-managed) ├─ r/ optional system-R kernel worker (requires jsonlite) ├─ skills/ Bundled SKILL.md catalog for reusable scientific workflows ├─ mcp-servers/ Bundled MCP servers (bio-tools: ~80 DB clients) └─ seed/ Bundled demo session recordings (CRISPR / enzyme / extremophile / immunotherapy) ``` ## Prerequisites - **Rust** (stable, 1.88+) with `wasm32-unknown-unknown`: `rustup target add wasm32-unknown-unknown` - **uv** (Python environment manager): <https://docs.astral.sh/uv/> - Optional: **R** with `Rscript` on PATH and the `jsonlite` package for the persistent `r` tool. Wisp never installs R packages automatically. - **Trunk** (WASM frontend bundler): `cargo install --locked trunk` - **Tauri CLI v2**: `cargo install tauri-cli --version "^2"` - **WebView2 Runtime** (Windows only) — Windows 10/11 usually has the Evergreen Runtime, and the installer acquires it
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Read on GitHubWould you bet a product on this? Bounded 0–100 and slow moving.
matched fp:99b80bfa29fba173, topic:mcp, topic:model-context-protocol, readme:model context protocol
matched fp:99b80bfa29fba173, topic:bioinformatics, topic:scientific-computing, desc:bioinformatics